Optional Topic 2 (for MSc degree)
From mn/safe/nukwik
Radiopharmaceutical chemistry
Subtopics
- production of radionuclides o in cyclotrons
- in nuclear reactor o with radionuclide generators
- radionuclidic purity
- target chemistry
- radiopharmaceutical chemistry
- types of organic molecules and other compounds to be labeled
- labeling chemistry of 11C
- labeling chemistry of 18F
- radioiodinations (123I and 124I)
- labeling chemistry of metal radionuclides (68Ga, 111In, 64Cu, 99mTc)
- radiochemical purity
- quality control and regulatory issues
- PET and SPECT imaging
- instrumentation
- pharmacokinetics and modeling
- applications in
- diagnostics (oncology, cardiology, neurology and psychiatry, gene expression and cell trafficking)
- drug development
- medical research
- therapeutics