Optional Topic 2 (for MSc degree)

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Radiopharmaceutical chemistry

Topics: - production of radionuclides o in cyclotrons o in nuclear reactor o with radionuclide generators o radionuclidic purity o target chemistry - radiopharmaceutical chemistry o types of organic molecules and other compounds to be labeled o labeling chemistry of 11C o labeling chemistry of 18F o radioiodinations (123I and 124I) o labeling chemistry of metal radionuclides (68Ga, 111In, 64Cu, 99mTc) o radiochemical purity - quality control and regulatory issues - PET and SPECT imaging o instrumentation o pharmacokinetics and modeling - applications in o diagnostics (oncology, cardiology, neurology and psychiatry, gene expression and cell trafficking) o drug development o medical research o therapeutics