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NeSys is a computational neuroanatomy and neuroinformatics laboratory. We aim at producing new neuroinformatics capabilities, as well as knowledge about design principles of large scale brain circuits, including circuit reorganization in disease models.
The laboratory develops database applications for image data, methods for computerized data acquisition, 3-D reconstruction, visualization and quantitative analyses of large neuronal populations and brain regions in the mammalian brain. The methods are employed to investigatethe architecture of large projection systems in the mammalian brain, as well as to study whole brain distribution patterns for gene, molecular,and circuit level data.
The laboratory employs stereotaxic surgery, electrophysiology, axonal tracing, general histology, immunocytochemistry, large scale microscopy image acquisition, shared tools for visualization and analyses, and shared online database applications. Project collaborations also include the use of high-resolution magnetic resonance imaging and positron emission tomography.
Several investigations are conducted in collaboration with leading laboratories in Europe and the U.S.A. The NeSys laboratory also has an experimental division performing experiments on rat and mouse models.
