CrossSeeds
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About
In the CrossSeeds project, our working hypothesis that AD, PD and HD share common pathways of protein aggregation and that cross-seeding of pathogenic pGlu-modified proteins are leading to neurodegeneration. On this page we show examples of pGlu-protein expression sites in rat and mouse models allowing visualization in 3D reference atlas space (Waxholm rat brain atlas and Allen brain mouse atlas). A database in preparation will allow storage of all raw data, retrieval and dissemination of findings to the scientific community.
Access image repository
The virtual microscopy filmstrip viewer allows interactive zooming and panning of images. The Localizoom link allows to visualize the sections together with customized reference atlas overlays. The names of atlas delineations are seen when pointing the mouse over the region of interest and 3D coordinates of the point are displayed live while moving the mouse. These 3D coordinates can also be collected and exported.
Zooming in a specific area is possible using the mouse wheel. Transparency of the atlas is adjustable on the top left corner scale.
AD mouse tg2576
This 18 month old Alzheimer’s mouse was labelled with 4 different antibodies against human APP (1D1), against APP and Abeta (4G8), against Abeta but not APP (MOAB-2) and against pGlu-Abeta.
1D1
- 761_2222_2904_Mtg01_bl1_1D1_s014 Localizoom
- 761_2222_2904_Mtg01_bl1_1D1_s028 Localizoom
- 761_2222_2904_Mtg01_bl1_1D1_s041 Localizoom
MOAB2
- 761_2222_2942_Mtg01_bl1_MOAB2_s015 Localizoom
- 761_2222_2942_Mtg01_bl1_MOAB2_s091 alignii
- 761_2222_2942_Mtg01_bl1_MOAB2_s143 alignii
pGlu
- 761_2222_2943_Mtg01_bl1_pGlu_s032 alignii
- 761_2222_2943_Mtg01_bl1_pGlu_s092 alignii
- 761_2222_2943_Mtg01_bl1_pGlu_s144 alignii
4G8
- 761_2222_2941_Mtg01_bl1_4G8_s026 alignii
- 761_2222_2941_Mtg01_bl1_4G8_s090 alignii
- 761_2222_2941_Mtg01_bl1_4G8_s154 alignii
